課程資訊
課程名稱
高溫腫瘤學
HYPERTHERMIA-BIOLOGY,PHYSICS AND INSTRUMENTATION 
開課學期
99-1 
授課對象
工學院  醫學工程學研究所  
授課教師
林文澧 
課號
Biomed7049 
課程識別碼
548 M0840 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期五6,7,8(13:20~16:20) 
上課地點
 
備註
本課程中文授課,使用英文教科書。本課程中文授課,使用英文教科書。教室:基醫402
總人數上限:30人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/991Biomed7049 
課程簡介影片
 
核心能力關聯
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課程大綱
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課程概述

1.Historical review
2.Biological principles
 a.Molecular and cellular mechanism of hyperthrmia
 b.Thermotolerance
 c.Interaction of heat and radiation
 d.Interaction of heat and drug
 e.Thermal dosimetry
3.Pathophysiological mechanisms
a.Microvasculature and perfusion in normal tissues and tumors
b.Metabolic status and reaction to heat of normal and tumor tissue
c.Manipulation of physiological parameters during hyperthermia
4.Physical principles and instrumentations
a.Electromagnetic heating technology
b.Ultrasound heating technology
c.Interstitial and intracavitary heating technology
d.Thermometry and thermal control
e.Thermal models and power deposition models
f.Treatment planning and quality assurance
5.Clinical applications of hyperthermia
a.Clinical rationale for thermoradiotherapy
b.Clinical rationale for thermochemotherapy
c.Thermoradiotherapy for superficial tumors
d.Thermoradiotherapy for deep tumors
e.Whole-body hyperthermia
6.Future clinical research
a.Considerations for hyperthermia clinical trials design
b.Standardized thermoradiotherapy treatment documentation
c.Tabulation of parameters for hyperthermic data evaluation

持續改善:因應每屆修課學生背景不同而調整授課內容或難易度


 

課程目標
了解利用溫度配合藥物下,腫瘤的表現,如存活率 復發等等 
課程要求
期未報告:
一人交一份期未報告
於期未前兩週公佈相關題目
依題目要求尋找三至五篇相關paper
整理成一份書面報告及簡報檔
並於學期未上台做十五~二十分鐘的內容報告。  
預期每週課後學習時數
 
Office Hours
另約時間 
指定閱讀
無 
參考書目
1.Seegenschmiedt MH, Fessenden P, and Vernon CC, 1995, Thermradiotherapy and
Thermochemotherapy Vol. 1 and 2, Springer.
2.Matsuda T, 1993, Cancer treatment by Hyperthermia, Radiation and Drugs, Taylor
& Francis. 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
Report (about 8 pages) 
50% 
 
2. 
Presentation for current journal papers. 
50% 
 
 
課程進度
週次
日期
單元主題
第1週
9/17  1.Historical review
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第2週
9/24  2.Biological principles
 a.Molecular and cellular mechanism of hyperthrmia
 b.Thermotolerance
 c.Interaction of heat and radiation
 d.Interaction of heat and drug
 e.Thermal dosimetry
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第3週
10/01  2.Biological principles
 a.Molecular and cellular mechanism of hyperthrmia
 b.Thermotolerance
 c.Interaction of heat and radiation
 d.Interaction of heat and drug
 e.Thermal dosimetry
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第4週
10/08  2.Biological principles
 a.Molecular and cellular mechanism of hyperthrmia
 b.Thermotolerance
 c.Interaction of heat and radiation
 d.Interaction of heat and drug
 e.Thermal dosimetry
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第5週
10/15  3.Pathophysiological mechanisms
a.Microvasculature and perfusion in normal tissues and tumors
b.Metabolic status and reaction to heat of normal and tumor tissue
c.Manipulation of physiological parameters during hyperthermia
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第6週
10/22  4.Physical principles and instrumentations
a.Electromagnetic heating technology
b.Ultrasound heating technology
c.Interstitial and intracavitary heating technology
d.Thermometry and thermal control
e.Thermal models and power deposition models
f.Treatment planning and quality assurance
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第7週
10/29  4.Physical principles and instrumentations
a.Electromagnetic heating technology
b.Ultrasound heating technology
c.Interstitial and intracavitary heating technology
d.Thermometry and thermal control
e.Thermal models and power deposition models
f.Treatment planning and quality assurance
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第8週
11/05  4.Physical principles and instrumentations
a.Electromagnetic heating technology
b.Ultrasound heating technology
c.Interstitial and intracavitary heating technology
d.Thermometry and thermal control
e.Thermal models and power deposition models
f.Treatment planning and quality assurance
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第9週
11/12  4.Physical principles and instrumentations
a.Electromagnetic heating technology
b.Ultrasound heating technology
c.Interstitial and intracavitary heating technology
d.Thermometry and thermal control
e.Thermal models and power deposition models
f.Treatment planning and quality assurance
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第10週
11/19  4.Physical principles and instrumentations
a.Electromagnetic heating technology
b.Ultrasound heating technology
c.Interstitial and intracavitary heating technology
d.Thermometry and thermal control
e.Thermal models and power deposition models
f.Treatment planning and quality assurance
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第11週
11/26  4.Physical principles and instrumentations a.Electromagnetic heating technology b.Ultrasound heating technology c.Interstitial and intracavitary heating technology d.Thermometry and thermal control e.Thermal models and power deposition models f.Treatment planning and quality assurance ﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第12週
12/03  4.Physical principles and instrumentations a.Electromagnetic heating technology b.Ultrasound heating technology c.Interstitial and intracavitary heating technology d.Thermometry and thermal control e.Thermal models and power deposition models f.Treatment planning and quality assurance ﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第13週
12/10  停課一週 
第14週
12/17  6.Image-guided thermal therapy: MRI guided focused ultrasound, Ultrasound-guided focused ultrasound
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第15週
12/24  7.Future research: Hyperthermia to enhance nanodrug delivery, Thermal therapy and pulsed focused ultrasound to induce immunotherapy, Combination of thermotherapy with chemotherapy for tumor treatment.
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第16週
12/31  7.Future research: Hyperthermia to enhance nanodrug delivery, Thermal therapy and pulsed focused ultrasound to induce immunotherapy, Combination of thermotherapy with chemotherapy for tumor treatment.
﹝舊版核心能力:1,2,3,4,5,6,7,8;新版核心能力:1,2,3,4,5,6,7﹞ 
第17週
1/07  學生期未報告 
第18週
1/14  學生期未報告 
第18-1週
1/14  課程期末問卷